منابع مشابه
EACR Travel Fellowship Awards
A key characteristic of malignant cancers is the ability to overcome microenvironmental controls by host, invade tissue, and reach distant sites of the body to form metastases. Cancer cells can induce profound changes in the neighbouring tissue, which in turn provides an environment that favours local tumour growth, metastatic spreading, and contributes to drug response. The host microenvironme...
متن کاملEACR Travel Fellowship Awards
Rabs are initially synthesized as soluble proteins; for membrane attachment they require a posttranslational C20-prenylation. Rab GTPases are localized to the cytosolic face of the limiting membrane of organelles, where they function as regulators of distinct steps in membrane trafficking pathways. Rabs cycle between a GTP-bound active and a GDPbound inactive form, assisted by GEFs (guanine nuc...
متن کاملEACR Travel Fellowship Awards
Prostate cancer as well as other solid cancers are embedded in and supported by the surrounding tumour microenvironment, which usually consists of fibroblasts, smooth muscle cells, endothelial cells and immune cells. In the prostate, fibroblasts and smooth muscle cells represent the bulk of the stroma in both normal and malignant conditions. In carcinomas, there are also pro-tumourigenic cancer...
متن کاملEACR Travel Fellowship Reports
The detoxifying enzymes can influence the efficacy and toxicity of chemotherapy and also the risk for the devlopment of leukemia. Acute lymphoblastic leukemia, the most common pediatric cancer, is a complex disease determined by a combination of genetic and environmental factors.Important environmental carcinogens are detoxified through the glutathione S-transferases(GSTs) system which includes...
متن کاملEACR Travel Fellowship Awards
GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) is a novel organoarsenical compound presently completing phase I trials in cancer patients who are refractory to treatment. GSAO targets the mitochondria of proliferating endothelial cells by binding to calcium-replete adenine nucleotide translocase on the inner mitochondrial membrane. Consequently, small solutes equilibrate across th...
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ژورنال
عنوان ژورنال: Psychiatric Bulletin
سال: 1992
ISSN: 0955-6036,1472-1473
DOI: 10.1192/pb.16.3.161-a